REBORN POLY-L-LACTIC ACID (PLLA) INSTRUCTIONS

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PLLA is a biocompatible, biodegradable, synthetic polymer of lactic acid that has been widely used in biomedical applications including sutures, orthopedic devices, and drug delivery systems for many years. Its ability to stimulate subclinical granulomatous inflammation resulting in extracellular collagen deposition accounts for its use in soft tissue augmentation.

Desired outcomes require predictability. Note that biocompatibility has been defined in the bioengineering literature as [the ability of a material to elicit an appropriate host response in a specific application". Biocompatibility in the specific application of soft tissue augmentation with all collagen stimulatory products, including PLLA, is therefore contingent upon the predictability of the material (product ), the host (patient), as well as how it`s used (the methodology). Much has now been learned about how to optimize outcomes and avoid adverse events with PLLA.

( PLLA )has been FDA approved since 1999 and has been used as an important facial filling material.

Since that time, PLLA has been increasingly used [off label" for soft tissue augmentation both on and off the face (i.e. buttocks) as well as for improvement of skin laxity (face, décolleté, arms, abdomen).